Second generation of nucleotide analogues

Abstract

The most common type of modification of a phosphorus center is the replacement of one or two non-bridging atoms of the phosphate group with different heteroatoms (e.g., sulfur, selenium) or groups of atoms (e.g., methyl, borane). Such compounds are referred to as the first generation of nucleotide analogues. We were interested in exploring the possibility of further functionalizing of the heteroatoms present in nucleoside phosphorothioates, phosphoroselenoate or boranephosphonates to create a second generation of nucleotide analogues with hopefully new biological properties. Here we report a preliminary account of our work on introducing additional modifications on the sulfur or selenium heteroatom of nucleotide analogues.

Graphical Abstract

Keywords:

• Phosphorothioates
• phosphoroselenoates
• boranephosphonates
• nucleotide analogues

Additional information

Funding

Financial support from the National Science Centre, Poland (the Preludium grant Nr 2018/31/N/ST5/03589 to JG), is greatly acknowledged.