New method for the syntheses of 2-aminoethyldiphenylphosphine oxides under the phase transfer conditions using cesium carbonate

Abstract

A simple one-pot method for the synthesis of 2-aminoethyldiphenylphosphine oxides is developed based on readily available diphenyl(2-phenoxyethyl)phosphine oxide and amines of different types under phase transfer catalysis conditions using anhydrous cesium carbonate as a base in acetonitrile or DMSO.

Graphical Abstract

Keywords:

• β-functionalized ethyldiphenylphosphine oxides
• oxide
• diphenylvinylphosphine oxide
• nucleophilic addition
• NH-alkylation

Additional information

Funding

This work was performed with the financial support from the Ministry of Science and Higher Education of the Russian Federation using the equipment of the Center for Collective Use of NRS «Kurchatov Institute»—IREA and the Center for Molecular Composition Studies of INEOS RAS.