Ionic liquid-promoted synthesis of phosphinates and other derivatives

Abstract

This conference proceeding is devoted to the ionic-liquid (IL)-promoted microwave (MW)-assisted synthesis of phosphinates with an outlook to the synthesis of other phosphinic acid derivatives such as thiophosphinates and phosphinic amides. The classical method for their synthesis involves the reaction of phosphinic chlorides with alcohols/phenols, thiols or amines that means cost, and goes with the formation of hydrochloric acid. To address these drawbacks, a more favorable alternative is offered applying MW irradiation and ionic liquids (ILs) as the catalysts. This beneficial combination allows the direct reaction of phosphinic acids with nucleophiles to afford phosphinic acid derivatives in variable yields.

Graphical Abstract

Keywords:

• Phosphinic derivatives
• phosphinates
• ionic liquids
• esterification
• microwave

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00130/19/7), New National Excellence Program of the Ministry of Human Capacities (ÚNKP-21-5-BME-333) and by the National Research, Development and Innovation Office (K134318).