Phosphonodithioformate-amine coupling reaction: from basic discovery to application for the functionalization of liposomes

Abstract

This short review article is dedicated to the Phosphonodithioformate-Amine Coupling (PAC) reaction. This reaction occurs by mixing phosphonodithioformate with amine without any catalyst and produces, according to a fast second order kinetics, phosphonothioamide. This reaction was applied to the functionalization of liposomes and opens new possibilities for the functionalization of synthetic or biologic materials.

Graphical Abstract

Keywords:

• Click reaction
• phosphonothioamide
• liposomes
• reaction in water
• phosphonate

Acknowledgements

We thank IBSAM, CNRS and the University of Brest (UBO).