A simple, one-pot method for the synthesis of functionalized selenazole derivatives

Abstract

A simple, one-pot synthesis of six highly functionalized selenazole derivatives has been achieved in moderate to good yields via a three-component condensation of variously substituted hydrazines, potassium selenocyanate, aroyl chlorides, and dimethyl acetylenedicarboxylate in acetone at room temperature. The structures of the compounds were deduced from elemental analysis and their infrared (IR), ⁷⁷Se nuclear magnetic resonance (NMR), ¹H NMR, and ¹³C NMR spectra. This new protocol offers advantages such as mild reaction conditions, easy work-up, and high yields.

Graphical abstract

Keywords:

• Aryl hydrazines
• aroyl chlorides
• potassium selenocyanate
• dimethyl acetylenedicarboxylate
• selenazole derivatives

Conflict of interest

The authors confirm that this article content has no conflict of interest.