Phosphino Isoxazolidines: an Approach to Regio and Stereoselective Synthesis

Abstract

The 1,3-dipolar cycloaddition of nitrones to vinyl phosphorus derivatives, mainly phosphines and their oxides and sulfides, has been studied. The cycloaddition to chiral racemic phosphine oxides and sulfides gives adducts with considerable diastereofacial selectivity. The transition state model for the cycloaddition is discussed.