SYNTHESIS OF SOME HETEROCYCLIC COMPOUNDS CONTAINING PYRIDOPY RIMIDINE

Abstract

5,6,7,8-Tetrahydro-3-amino-2-methyl-l[2H-thioxoisoquinoline-4-carbonitrile (2) reacted with carbon disulphide in alcoholic KOH followed by acidification with HCI to produce pyrirnidotetrahydroisoquinoline dithiole (3), which when allowed to react with halocompounds, gave the compounds (5–9). It also reacted with acrylonitrile to produce compound (10). When compound (2) was allowed to react with ethylorthoformate in the presence of Ac₂O, the corresponding ethoxy azornethene derivative (11) was obtained, which when allowed to react with amines or hydrazine, in order to obtain pyrimidoisoquinoline (12), produced mainly the starting material (2).

Key Words:

• Synthesis
• tetrahydroisoquinolinthione
• pyrimidotetrahydroisoquinolinthione