SOLID-STATE CONFORMATIONS OF FIVE MEMBERED RING PHOSPHORUS HETEROCYCLES: X-RAY CRYSTAL STRUCTURES OF THREE 1,3,2-OXAZAPHOSPHOLANES

Abstract

Single-crystal X-ray structural determinations have been made on (2S,4R,5R)-2-phenoxy-2-oxo-3,4- dimethyl-5-phenyl-l,3,2-oxazaphospholane, 1; (2S,4R,5R)-2-(dimethylamino)-2-oxo-3,4-dimethyl-5- phenyl-l,3,2-oxazaphospholane, 2; and (2S,4R,5S)-2-phenoxy-2-oxo-3,4-dimethyl-5-phenyl-l,3,2- oxazaphospholane, 3. The solid-state conformations adopted by these materials are P(2) half-chair, envelope C(4), and P(2) half-chair. respectively.

Key Words:

• Oxazaphospholane
• conformation structure
• X-ray crystal
• ephedrine
• pseudoephedrine