Synthesis and Antimicrobial Activity of Some 2(1H)-quinoxalinone-6-sulfonyl Derivatives

The synthesis of some quinoxalinesulfonyl derivatives is described. Two of the synthesized derivatives, 2-oxo-1,2-dihydroquinoxaline-6-sulfonyl azide (3a) and 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (3b), were screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and seven strains of Gram-negative bacteria, along with two fungal isolates. The two compounds showed broad spectrum (in vitro) activity against the bacterial strains.

Keywords:

• 2-Oxo-1,2-dihydroquinoxaline-6-sulfonyl azide
• 2,3-dioxo-1,2,3,4-tetra-hydroquinoxaline-6-sulfonyl azide
• antimicrobial activity
• synthesis

Notes

*Microwave-assisted method.

*in DMSO-d₆ solvent.

**in CDCl₃ solvent.