Synthesis of 2-Aminoaryl-5-Substituted-1,3,4- Thiadiazoles in a Thermal 1,3-Dipolar Cycloaddition Reaction

The preparation of a series of new 2-aminoaryl-1,3,4-thiadiazoles substituted with methylsulfanyl, methansulfinyl, or amine in the 5-position is described in this article. The compounds were obtained from N-hydroxyimidoyl chlorides and methyl dithiocarbazinate or 4-substituted thiosemicarbazides in a thermal 1,3-dipolar cycloaddition reaction. The new derivatives were tested for their activity against Mycobacterium tuberculosis.

Keywords:

• 1,3-Dipolar cycloaddition
• 1,3,4-thiadiazoles
• 4-substituted thiosemicar-bazides
• antituberculosis activity
• hydroxamoyl chlorides
• methyl dithiocarbazinate