Compounds 2 and 9 were formed using 3-(4-chloro-phenyl)-1-pyridin-2-yl propenone ( 1 ) and malononitrile or ethyl cyanoacetate, respectively. The pyridine derivative 2 was in turn used as a precursor for the preparation of some pyridopyrimidine and fused pyridopyrimidine derivatives 3–8 On the other hand, the pyridine derivative 9 was used for the preparation of thienopyridine derivatives 11 and 12 Nitrozation of compound 12 afforded pyridothienotriazine derivative 13 Some of the prepared products showed potent antimicrobial activity.
Phosphorus, Sulfur, and Silicon and the Related Elements
Volume 180, 2005 - Issue 12
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