Synthesis, Reactions, and Antiviral Activity of 5′-Acetyl-6′-methyl-2′-thioxo-1′,2′-dihydro-3,4′-bipyridine-3′-carbonitrile

Bipyridine-3′0-carbonitrile derivatives 5 reacted with several halogen containing reagents, e.g., 1-chloroacetone, 3-chloropentan-2,4-dione, ethyl chloroacetate, ethyl 2-chloro-3-oxobutanoate, 2-chloroacetamide, chloroacetonitrile, and iodomethane to afford the corresponding thieno[2,3-b]-pyridine derivatives. Considering the data of IR, ¹H NMR, mass spectra and elemental analysis the chemical structures of the newly synthesized heterocyclic compounds elucidated. Cytotoxicity, anti-HSV1, (anti-Herpes Simplex virus type 1) anti-HAV (Hepatitis A virus), and MBB activity were evaluated for the newly synthesized heterocyclic compounds.

Keywords:

• 2-Cyanoethanethioamide
• 2-methyl-thiopyridine-3′-carbonitrile
• 2-thioxopyridine
• bipyridine-3′-carbonitrile
• thieno[2,3-b]pyridine