SULFONATE ESTER-CONTAINING (IMIDAZOL-1-yl)- N-SUBSTITUTED BENZENESULFONAMIDES OF ANTICIPATED ANTINEOPLASTIC ACTIVITY

Abstract

The stereospecific synthesis for a series of (Z)-4-{2-Aryl-4-[4-(arylsulfonyloxy)phenylmethinyl]-4,5-dihydro-5-oxo-1H-imidazol-1-yl)-N-substituted benzenesulfonamide derivatives (VIa-o) was investigated with a view to prepare new pharmacologically active products of extended and/or improved antineoplastic activity. Owing to the weak nucleophilicity of the nitrogen nucleophiles under investigation, acetic acid mediated cyclizations were followed for preparation of the required products. Additionally, the antimicrobial activity was screened for the compounds reported.

Key Words:

• Sulfonamide derivatives
• stereospecific synthesis
• antimicrobial activity.