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Communication

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW HETEROCYCLIC QUINOLINE DERIVATIVES

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Pages 293-301 | Received 03 May 1990, Accepted 17 Aug 1990, Published online: 28 Aug 2008
 

Abstract

Alkylation of 2-mercapto-3-cyano-4-aryl-5,6,7,8-tetrahydroquinoline (I) gave compounds II–IV. Cyclization of III and IV afforded thienoquinolines V and VI respectively. On diazotization of V and VI, the corresponding triazinone derivatives VII and VIII were obtained. Also, reaction of V with benzoyl chloride yielded the tetracyclic compound IX. Structures of the new compounds were established by their elemental analyses and spectral data. Some of these compounds were screened in vitro for their antibacterial activities.

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