Abstract
The analogues of biologically active ophthalmic (γ-L-glutamyl-α-L-aminobutyrylglycine) and norophthalmic (γ-L-glutamyl-L-alanylglycine) acids containing the phosphonic analogue of glycine or glycolic acid have been synthesized by standard procedure. The key intermediates were P-terminal di-p-nitrobenzyl phosphonodipeptides and phosphonodidepsipeptides derivatives of amino and hydroxymethyl-phosphonic acids.