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Abstract
3-Cyanoquinoline-2(1H)-thione (1) was reacted with some halocompounds to give S-substituted thioquinoline derivatives 2, 6 and 7. Cyclization of 7 yielded thienoquinoline 8. Also, reaction of 1 with chloroacetone, chloroacetonitrile, ethyl chloroacetate and chloroacetamide furnished thienoquinolines 3, 4, 5 and 8, respectively. Moreover, compounds 4 and 8 underwent different sequence reactions to give some new pyrimido- and triazino-[4′,5′:4,5]thieno[2,3-b]quinoline derivatives (9–21). Most of the prepared compounds were screened in vitro for their antibacterial activities.
