REACTIONS WITH CYANOTHIOACETAMIDE DERIVATIVES: A NEW ROUTE FOR THE SYNTHESIS OF 2-THIAZOLIN-4-ONE THIAZOLO[4,5-B]PYRIDINE, THIAZOLINONYLPYRAZOLE AND PYRANO[2,3-d]-1,3-THIAZOLE DERIVATIVES

Abstract

Several new 2-thiazolin-4-one, thiazolo[4,5-b]pyridine, thiazolin-4-on-2-yl pyrazole and pyrano[2,3-d]-1,3-thiazole derivatives were synthesised via the reactions of 2-α-cyanoacetonyl-2-thiazolin-4-one with a variety of α,β-unsaturated nitriles and other reagents. Structural elucidations were based on elementary analyses and spectral data studies.

Key Words:

• Cyanothioacetamide
• 2-thiazolin-4-ones
• thiazolo[4,5-b]-pyridines
• pyrano[2,3-d]-1,3-thiazoles
• thiazolinonylpyrazoles