A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES

Patrick Page Laboratoire Synthèse, Structure et Réactivité de Molécules Phosphorées (URA CNRS 454), 118 Route de Narbonne, 31062, Toulouse Cedex, France

Marie-Rose Mazières Laboratoire Synthèse, Structure et Réactivité de Molécules Phosphorées (URA CNRS 454), 118 Route de Narbonne, 31062, Toulouse Cedex, France

Jacques Bellan Laboratoire Synthèse, Structure et Réactivité de Molécules Phosphorées (URA CNRS 454), 118 Route de Narbonne, 31062, Toulouse Cedex, France; Laboratoire de Chimie Pharmaceutique, Université Paul Sabatier, 118 Route de Narbonne, 31062, Toulouse Cedex, France

Michel Sanchez Laboratoire Synthèse, Structure et Réactivité de Molécules Phosphorées (URA CNRS 454), 118 Route de Narbonne, 31062, Toulouse Cedex, France

Bruno Chaudret Laboratoire de Chimie de Coordination du CNRS Unité 824 liée par convention à l′Université Paul Sabatier et à l′Institut National Polytechnique de Toulouse, 205 Route de Narbonne, 31077, Toulouse Cedex, France

Abstract

The Michaelis-Becker-Nylen reaction is well suited for the synthesis of 2-phosphonomethyl pyridines. We have improved this four steps method in a one pot reaction using commercial reagents. By this general procedure we have prepared seven new 2-phosphonomethyl pyridines (Ia—g) under mild conditions with higher yields.

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A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES

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A SIMPLE AND CONVENIENT SYNTHESIS OF 2-PHOSPHONOMETHYL PYRIDINES

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