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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 70, 1992 - Issue 1
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Original Articles

REACTIONS OF PHENYL ISOTHIOCYANATE AND SULFUR WITH DIMERIC ADDUCTS: NOVEL SYNTHESIS OF THIAZOLES, THIAZOLO-[4,5-d]PYRIMIDINE AND THIAZOLO[4,5-d]-PYRIDINE DERIVATIVES

Rafat M. Mohareb Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
,
Hoda Z. Shams Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt
&
Yehia M. Elkholy Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt
Pages 317-324 | Received 03 Feb 1992, Accepted 16 Apr 1992, Published online: 26 May 2009
 
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Abstract

Dimeric adducts 1–3 react with phenyl isothiocyanate and sulfur to afford the thiazole derivatives 4, 12 and 14. The latter products react with different chemical reagents to afford new thiazoles and their fused derivatives which show high fungicidal and bactericidal activities.

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Related Research Data

Synthesis of Thiophenes, Azoles and Azines with Potential Biological Activity by Employing the Versatile Heterocyclic Precursor N-Benzoycyanoacetylhydrazine
Source: Wiley
Novel synthesis of pyran, thiophene, and pyridine derivatives incorporating thiazole ring and their antitumor evaluation
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