SYNTHESIS AND ANTICANCER SCREENING OF DIASTEREOISOMERIC 4,5-DIPHENYL- AND 3-METHYL-4,5-DIPHENYLCYCLOPHOSPHAMIDES

Milena Ivanova Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, 1040, Sofia, Bulgaria; Department of Experimental Cancer Therapy, Medical Academy, 1156, Sofia

Maria Lyapova Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, 1040, Sofia, Bulgaria; Department of Experimental Cancer Therapy, Medical Academy, 1156, Sofia

Zlatina Astardjieva Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, 1040, Sofia, Bulgaria; Department of Experimental Cancer Therapy, Medical Academy, 1156, Sofia

Jordan Stoychkov Institute of Organic Chemistry with Center of Phytochemistry, Bulgarian Academy of Sciences, 1040, Sofia, Bulgaria; Department of Experimental Cancer Therapy, Medical Academy, 1156, Sofia

Abstract

The four possible diastereoisomers of 4,5-diphenylcyclophosphamides (2–5) and their N-methyl analogues (6–9) have been synthesized via condensation of aminopropanols 10 and 11 (threo- and erythro) with bis-(2-chloroethyl)-phosphoramidic dichloride 12. Anticancer screening tests against L 1210 lymphoid leukaemia in mice did not show any therapeutic activity.

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SYNTHESIS AND ANTICANCER SCREENING OF DIASTEREOISOMERIC 4,5-DIPHENYL- AND 3-METHYL-4,5-DIPHENYLCYCLOPHOSPHAMIDES

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SYNTHESIS AND ANTICANCER SCREENING OF DIASTEREOISOMERIC 4,5-DIPHENYL- AND 3-METHYL-4,5-DIPHENYLCYCLOPHOSPHAMIDES

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