Abstract
The substituted benzo[a][1,4]benzothiazino[3,2-C]phenothiazines and 5H-benzo[a]phenothiazin-5-ones were prepared by the condensation of 2,3-dichloro-5-nitro-1,4-napthoquinones 1 with 2-amino-3,5disubstituted benzenethiols 2a and their zinc salts respectively. The resulting compounds were subjected to reduction, methylation and acetylation. Some of these compounds were screened for their antimicrobial activity against bacteria S. aureus and E. coli and fungi Aspergillus niger, Aspergillus flavus, Fusarium moniliformae and Curvularia lunata.