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Abstract
An efficient synthesis of a-phosphonothioamides is described, involving thioacylation of primary or secondary amines with a-phosphonodithioacid salts (prepared in situ), in the presence of boron trichloride. This method can also be used for the preparation of non-phosphorylated thioamides. In the same conditions and with thiophenol, a dithioacid sodium salt is converted into the S-aryldithioester, while an α-phosphorylated dithioacid sodium salt is reduced into the bis (phosphonomethyl) disulfide.