Chiral Thiazolidine-2-Thione Derived Iminium Salts as Reagents for Kinetic Resolution

Abstract

There are currently few simple reagent systems available which can effect efficient kinetic resolution of racemic compounds. We report here a series of chiral bicyclic iminium salts, which can resolve racemic secondary alcohols to give both the unreacted alcohol and the sulphide resulting from reaction in moderate enantiomeric excess.