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Abstract
Four N-phosphonoamino acid methyl esters have been synthesized. The structures were supported by 31P, 1H, NMR, IR and FAB-MS data. Two stereoisomers of each compound appeared in the 31P NMR spectra. N-(O-isopropyl methyl-phosphonyl)L-serine methyl ester was more reactive in acid than N-(O,O-diisopropyl) phosphoryl-L-serine ester, which underwent rapid N→O migration of the phosphorus group.