ETUDE PAR RMN DE L'ADDITION DES FONCTIONS -NH,-OH et P_v-H SUR L'ÉTHÉNYLIDÈNE BIS PHOSPHONATE DE DIÉTHYLE. SYNTHÈSE DE GEM BIS PHOSPHONATES FONCTIONNALISÉS

Abstract

Tetraethyl ethenylidene bis phosphonate can undergo facile Michaël type addition reaction with amines, alcohols, water, aminoacid and spirophosphoranes bearing a P[sbnd]H bond. The stability of these compounds was investigated and the reversibility of the reaction was demonstrated in the case of methylamine.

Key Words:

• Bis phosphonates
• spirophosphoranes
• ethenylidene gem bis phosphonate
• Michaël addition
• phosphorane-bis phosphonates
• diastéréotopie and stéréomutations