The Synthesis of Novel Derivatives of 1,5-Dihydro-4-Mercapto-2,6-Dioxo-1,3,5,2-Triazaphosphorine and Their Antitumor Activity

Abstract

A series of new derivatives of 1,5-dihydro-4-mercapto-2,6-dioxo-1,3,5,2-triazaphosphorine have been synthesized. The most stable tautomer was proven to have the thioenol form by spectroscopic data and quantum chemistry calculation. The preliminary bioassay indicated that the title compounds significantly inhibited the growth of jurkat cells in vitro as well as S-180 tumor in vivo.

Key Words:

• Triazaphosphorine
• synthesis
• derivatives
• antitumor activity
• structure confirmation.