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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 89, 1994 - Issue 1-4
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Original Articles

Synthesis and Properties of Novel Nitrogen Mustard Linked Phosphoryl Diamide Derivatives

Ru-Yu Chen Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People's Republic of China
,
Li-Juan Mao Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People's Republic of China
,
Hui-Lin Wang Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People's Republic of China
&
Jia Zhou Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, People's Republic of China
Pages 89-95 | Received 27 Dec 1993, Accepted 28 Mar 1994, Published online: 23 Sep 2006
 
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Abstract

Two series of novel phosphoryl diamide derivatives (3, 4) containing the nitrogen mustard group were synthesized, and the effects of substituents on the reactivity and the spectral properties are discussed. All the compounds prepared were confirmed by 1H NMR, IR, MS, 31P NMR and elemental analysis. Preliminary bioassays indicate that compounds 3 have good antitumor activities, and some of compounds 4 display high inhibitory activities against the tobacco mosaic virus (TMV).

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