Abstract
Single crystal X-ray structure analysis confirms the existence of two geometrical isomers of 5,13-diphenyl-1,9-dioxa-5,13-diphosphacyclohexadecane. In the solid state, the trans isomer has exact C ; symmetry while the cis isomer shows virtual C2 . symmetry. Pairs of oxygen donor atoms are directed to opposite sides of the macrocycle in each ligand; in the cis-isomer, the phosphine oxide oxygens lie on the same side of the macrocycle, opposite to the ring ether oxygens while in the trans-isomer one phosphine oxide and one ether oxygen lie opposite to their symmetry-related counterparts. In solution, each isomer is identifiable by 13C and 31P NMR but analysis of mixtures in the latter case is complicated by concentration-dependent chemical shifts.