SYNTHESIS OF N-(HYDROGEN METHYLPHOSPHONOTHIONYL), N-(O-METHYL METHYLPHOSPHONOTHIONYL) AMINO ACID METHYL ESTERS AND THEIR ANTIMICROBIAL ACTIVITIES

Abstract

The synthesis of some N-(hydrogen methylphosphonothionyl) amino acid methyl esters (II-VII) and N-(O-methyl methylphosphonothionyl) amino acid methyl esters (VIII-XIII) is described. Reaction of methyl iodide with compounds (II-XIII) afforded the corresponding methyl iodide quaternary salt derivatives (XIV-XXV). All the synthesized compounds were found to possess high and moderate antimicrobial activities towards a number of microorganisms.

Key Words:

• N-(hydrogen methylphosphonothionyl)
• N-(O-methyl methylphosphonothionyl)
• amino acid esters and antimicrobial activities.