STEREOSELECTIVE WAY TO DERIVATIVES OF N-PHOSPHORYLATED AMINO ACIDS

Abstract

Stereoselective synthesis of the N-phosphor (V) substituted amino acids (2, 3) via the N-phosphor (III) derivatives of amino acids (1) are described. The diastereoisomers of N-phosphor (V) amino acids are separated by crystallization or column chromatography and used as starting compounds for preparation of chiral N-chloroamides. The prepared compounds have been characterized by NMR spectra and HPLC.

Key Words:

• N-phosphor (III) substituted L-leucine esters
• N-thiophosphor (V) substituted L-leucine esters
• N-phospor (V) substituted L-leucine esters
• N-chloro-N-phosphor (V) amino acids esters
• diastereoisomers
• stereoselectivity
• NMR spectra
• HPLC