ETUDE DÉS REACTIONS DE KABACHNIK-FIELDS ET DE MOEDRITZER-IRANI. I RÉACTION DU TRANS DIAMINO 1,2-CYCLOHEXANE DL

Abstract

The Kabachnik-Fields and Moedritzer-lrani reactions are studied in the case of 1-2 diamino trans cyclohexane dl as aminated component. The new bicyclic bis phosphonates 1, 1′, la have been obtained in the first case and the tetra phosphonic acid 2′ in the second one. The methylene bridge between the two nitrogen atoms in 1 and la is a protecting group that is stable in basic medium and readily removed at 20°C in acidic conditions. The ¹H, ³¹C and ³¹P spectra are reported for all new compounds.

Key Words:

• α-Amino phosphonates
• phosphonomethylation
• Kabachnik-Fields reaction
• bicyclic bis amino phosphonates
• Moedritzer-lrani reaction
• tetra phosphonic acid