HETEROCYCLIC SYNTHESIS WITH NITRILES: SYNTHESIS OF SOME NOVEL PYRROLE, PYRROLO[1,2-a]QUINAZOLINE AND PYRROLO[1,2-a]TRIAZINE DERIVATIVES

Abstract

α-(Bromothiocyanatomethyl) benzylidenemalononitrile 1 undergoes base catalysed reactions with primary aromatic amines, anthranilic acid derivatives and urea derivatives in refluxing ethanol to afford N-arylpyrrole-3-carbonitrile, pyrrolo[1,2-a]quinazolin-5-imine, pyrrolo[1,2-a]quinazolin-5-one and pyrrolo[1,2-a]triazine derivatives respectively.

Key Words:

• α-(bromothiocyanatomethyl) benzylidenemalononitrile
• N-arylpyrroles
• Pyrrolo[1,2-a]quinazolines
• pyrrolo[1,2-a]triazines