SYNTHESIS OF 8-SUBSTITUTED-2-CARBOXY-4-(4-FLUOROPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPINES

Abstract

Syntheses of six 8-substituted-2-carboxy-4-(4-fluorophenyl)-2,3-dihydro-1,5-benzothiazepines having as the substituent fluoro, chloro, bromo, alkyl-methyl, alkoxyl-methoxyl and ethoxyl have been achieved by the reaction of 5-substituted-2-aminobenzenethiols with β-(p-fluorobenzoyl)acrylic acid in ethanol saturated with hydrogen chloride gas. The products were tested for purity by TLC. Microestimation of nitrogen, IR and ¹H NMR & mass spectral studies have been used for the assignment of structures to the title compounds.

Key Words:

• 2,3-dihydro-1
• 5-benzothiazepines
• fluorine
• β-(p-fluorobenzoyl)acrylic acid