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Abstract
We have shown that thioesters of phosphoric acids of general formula (RO)2P(X)C[tbnd]CR1, were X=O or S, containing an acetylenic bond in α-position of the S-ester group has unugually high destructive effect on some isoforms of cytochrome P 450 of arthropods and mammals. These isoforms probably, participate in the process of inactivation of the acetylenic thioesters. We assume that this process may be thought as being a rupture of rhe P-S bond, which leads to the formation of killer particles - alkylthioketenes.