MICROWAVE INDUCED SYNTHESIS OF 2-SUBSTITUTEDPHENYL-3-(3-ALKYL/ARYL-5,6-DIHYDRO-S-TRIAZOLO) [2,4-B] [1,3,4] THIADIAZO 6-YL INDOLES AND 2-PHENYL-3 [2, SUBSTITUTED BENZOTHIAZOLE] DERIVATIVES AND THEIR FUNGICIDAL ACTIVITY

Abstract

The title compounds were synthesised by condensation of 3-alykl/aryl-4-amino-5-mercaptotriazole (II) and 5-substituted 2-aminothiophenols (IV) with appropriate 2-phenyl-1H-indole-3-carboxaldehyde (I) under microwave irradiation in the presence of piperidine/p-toluenesulphonic acid using ethanol/DMF as energy transfer media. The considerable increase in reaction rate with improved yield has been observed, using microwave as compared to classical method.

Key Words:

• Sulfur-containing indole derivatives: 4-amino-5-mercaptotazole
• 2-aminothiophenol
• benzothiazole
• triazolothiadiazoles
• microwave irradiation
• antifungal activity