Stereoselective Epoxidation of bis-Sulfinyl Alkenes and Application to the Asymmetric Synthesis of α-Substituted Carboxylic Acids

Abstract

Ketene thioacetals 3 can be easily prepared in optically pure form and react diastereoselectively with metal peroxides. The resulting bis-sulfinyl oxiranes can be converted in a single step to α-substituted acids.