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Original Articles

On the Acidity and Lithiation-Functionalization of Thiophenes: Revisited for their Use in the Synthesis of Thiophene-Based Novel π-Systems

Pages 401-402 | Published online: 17 Mar 2008
 

Abstract

When lithium diisopropylamide is used for lithiation and functionalization of thiophenes, whose acidity is here measured to be pKa = 35-36 in THF-Hex (5:3), the equilibrated nature of lithiation is to be taken into consideration.

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