Exploring Cage Chirality of Phosphorus Sulfide Amides and Imides

Abstract

Chirality of bicyclic P₄S₃ skeletons has been explored by reaction of α- or β-P₄S₃I₂ with enantiomerically pure or racemic H₂NCHMePh, to give diastereomers of products with one or two exocyclic amide substituents, or of cage structures containing a bridging imide group. ³¹P NMR spectra show diastereomeric differences in chemical shifts of all four phosphorus atoms in the product molecules. Comparison of observed with predicted numbers of diastereomers is a useful extra tool for identification of unseparated new compounds by NMR.

Keywords::

• chiral
• phosphorus
• cage
• NMR
• amide
• imide