REACTIONS OF STYRYLTHIENYL KETONE, STYRYL FURYL KETONE WITH THIOCYANOACETAMIDE: SYNTHESIS OF SEVERAL NEW PYRIDINES, THIENO[2,3-b]PYRIDINES, PYRIDO [2′,3′:4,5]THIENO[3,2-c]PYRIDAZINES AND PYRIDO-[3′,2′:4,5]THIENO[3,2-d]PYRIMIDIN ONE DERIVATIVES

Abstract

Styryl thienyl ketone and Styryl furyl ketone 2a, b reacted with thiocyanoacetamide(1) to give the dihydropyridinethiones 3a, b which used as starting material for the synthesis of several heterocyclic compounds. Reaction with several halogeno-esters, halogeno-ketones and chloroacetamide gave 2-S-alkoyl pyridines 5a-d, 10a-d, 13a, b and 19a, b thieno[2,3-c] pyridines 6a, b, 11a, b 14a, b and 20a-d, pyrido[2′,3′,4:5]thieno[2,3-c]pyndazines 8a, b and pyrido[2′.3′:-4,5]thieno[2,3-d]pyrimidinones 15a, b 16a, b and 17a, b. Structures were established based on elemental analyses and spectral data studies.