SYNTHESIS AND NMR CHARACTERIZATION OF DIPHENYL α-(BENZYLOXYCARBONYLAMINO)-BENZYL-PHOSPHONATES AND DIPHENYL 1-(BENZYLOXYCARBONYLAMINO)-ALKYL PHOSPHONATES

Abstract

A variety of the title phosphonic derivatives were synthesized in high yields starting from commercially available aldehydes. Complete NMR cheracterization is reported for all compounds, which are useful intermediates for the synthesis of the phosphorus analogs of natural enzymes or peptides.

Key Words:

• Phosphono-peptide intermediates
• isomeric ratio
• ¹H- and
• ³¹P-NMR