The Uses of 4-Aryl-3-Thiosemicarbazides in Heterocyclic Synthesis: Synthesis of Coumarin, Pyrazole, Thiazole and Thiophene Derivatives

Abstract

The reaction of 4-phenyl-3-thiosemicarbazide derivatives 1a-e with 3-aminoacetonitrile (2) gave the condensed products 3a-e. The reactivity of the latter products toward variety of chemical reagents was studied. Moreover, the reaction of 3b with phenylisothiocyanate; followed by cyclization with α-haloketones 6, 7 and 16, gave the thiazole and thiophene derivatives.

Keywords::

• Thiosemicarbazides
• aminoacetonitrile
• thiazole
• thiophene