A FACILE ONE STEP SYNTHESIS OF [3-(2-HYDRAZINO-4-THIAZOLYL) COUMARINO] DIMETHYL METHINES AND SOME 3-SUBSTITUTED-7H-6-(6/8,6,8-SUBSTITUTED-3-COUMARINO)-S-TRIAZOLO[3,4-b][1,3,4]THIADIAZINES

Abstract

Some [3-(2-hydrazino-4-thiazolyl) coumarino]dimethyl methine derivatives (III) have been prepared by the condensation of 3-(2-bromoacetyl)-coumarin and thiosemicarbazide in acetone. These compounds formation was further confirmed by the condensation of acetone thiosemicarbazone (I) and p-N,N-dimethyl amino benzaldehyde thiosemicarbazone (II) with 3-(2-bromoacetyl)coumarin in anhydrous ethanol and dimethyl formamide in a two step process. 3-Substituted-7H-6-(6 or 8 or 6,8-disubstituted 3-coumarino)-s-triazolo[3,4-b] [1,3,4]thiadadiazines (V) have also been prepared from simple condensation of appropriate 4-amino-5-mercapto-1, 2,4-triazole with various 3-(2-bromoacetyl) coumarins in anhydrous ethanol and dimethyl formamide.

Key Words:

• Thiadiazine
• thiazole
• thiazolyl coumarin