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Original Articles

CONDENSATION REACTION OF ß-TRIPHENYLGERMANYL PROPANOIC ACID WITH DIPHENYL α-AMINOPHOSPHONATES AND BIOACTIVITIES OF PRODUCTS

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Pages 41-49 | Received 07 Aug 1998, Accepted 28 Oct 1998, Published online: 24 Sep 2006
 

Abstract

The condensation reaction of β-triphenylgermanyl propanoic acid with diphenyl α-aminophosphonates was studied. A variety of novel diphenyl N-triphenylgermanylpropiono-α-aminophosphonates were synthesized successfully in good yields by using DCC catalyzed by pyridine. The structures of all of the products were confirmed by 1HNMR, 31PNMR, IR, MS and elemental analysis. The results of bioassay showed that the new products have good anticancer activities and very strong anti-inflammatory activities.

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