REVISED SYNTHESIS OF SOME NEW DERIVATIVES OF BIOLOGICAL INTEREST 2-HETEROCYCLIC BENZOTHIAZOLYL DERIVATIVES OF BIOLOGICAL INTEREST

Abstract

Substituted benzothiazole at position 2 by a heterocyclic ring has been prepared by the action of bifunctional compounds on the active intermediate a-2-benzoth: azolyl-β-arylaminoacrylonitrile (III). Compound III was obtained by refluxing a-2-benzothiazolyl-β, β-dimethylthioacrylonitrile (II) with aromatic amines in ethanol for a long time. Refluxing equimolar amounts of I11 and hydrazine, hydroxylamine, guandine ethylenediamine and ethanolamine in presence of DMF yielded the corresponding 2-pyra- 2010, isoxazolo, pyrimidino, 1,4-diazepino and 1,4-oxazepinobenzothiazole (V-IX), respectively. The structures of all newly prepared compounds have been confirmed by analytical and spectral data.