HETEROCYCLIC SYNTHESES WITH THIOLES AND NITRILES: SYNTHESIS OF SOME NEW PYRIMIDO[4′,5′:4,5] THIAZOLO[3,2-a], THIAZOLO[3,2-a] AND TRIAZOLO[3,2-a]-BENZIMIDAZOLE DERIVATIVES

Abstract

Treatment of 6-benzoylbenzimidazole-2-thiol(1) and 3-amino-6-benzoylthiazolo[3,2-a]-benzimidazole-2-carbonitrile (3) with various reagents under different conditions is reported to afford cyclized and uncyclized compounds of potential pharmacological interest.

Key Words:

• 4-chloroacetylantipyrine
• 2-bromodimedone
• hydrazonyl chloride