Synthesis of Biological Activities of Phosphorus-Containing Polycationic Strings

Abstract

Several series of phosphoruscontaining polycationic strings have been prepared. These include those in which quaternary phosphonium sites are located at regular intervals along a linear chain of defined length (“Strings”), and those in which the cationic phosphonium, sites are in linkages arrayed in branching arms about a cenhal focus unit (“baloons”). Polyphosphonium “balloon” arrays have been attached to a polystyrene backbone prowding a mataial which serves as an anionic exchange resin. PolyCationic strings have been prepared in which phosphorus is present a3 phosphine oxide functidties and the cationic sites are quatanary ammonium sites anayed at regular intervals along a linear chain of defined length. Several of the resultant materials have demonshated sigruficant antibaaaial activity. Interactions of the polycationic species with the anionic gmove region of double stranded DNA have been investigated.