Synthesis of 1,3,2-Oxazaphosphorinane Derivatives under the Phase Transfer Conditions

Anatoly Shipov A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Scienses, Vavilova str., 28, Moscow, 117813, Russia

Galina Genkina A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Scienses, Vavilova str., 28, Moscow, 117813, Russia

Oleg Artyushin A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Scienses, Vavilova str., 28, Moscow, 117813, Russia

Tatyana Mastryukova A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Scienses, Vavilova str., 28, Moscow, 117813, Russia

Martin Kabachnik A.N. Nesmeyanov Institute of Organoelement Compounds Russian Academy of Scienses, Vavilova str., 28, Moscow, 117813, Russia

Abstract

2-Aryloxy(or alkylthio)-Z-thio-l,3,2-oxazaphosphorinanes (I) possess a high nematocidic activity, as well as synergistic activity towards pyre-tluoid insecticides, being low toxic to mammals LD₅₀ 1000–3000 mg/kg, mice). In order to do these compounds more accessible a simple method of synthesis under the phase transfer conditions, using solid K₂CO₃ with 3 or 16 % of water and TEBA in CH₂Cl₂ or MeCN (yields up to 80 %) was elaborated according to the scheme:

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Synthesis of 1,3,2-Oxazaphosphorinane Derivatives under the Phase Transfer Conditions

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Synthesis of 1,3,2-Oxazaphosphorinane Derivatives under the Phase Transfer Conditions

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