Atropisomeric Transition State Analogs

Abstract

Atropisomerism is shown to be a useful design element for transition state analogs. A hydride transfer reaction between dihydroquinolines and ketones was mimicked using 1-substituted 2-naphthoamide derivatives.

Keywords::

• atropisomerism
• transition state analogs
• catalytic antibodies
• alcohol dehydrogenase
• 2-naphthoic acid derivatives