Effects of Bisphosphonates on the Inflammatory Processes of Activated Macrophages

Abstract

All bisphosphonates are similar in terms of their inhibitory effects on bone resorption, but seems to have different effects on inflammatory processes. For example, clodronate and tiludronate have anti-inflammatory and antiarthritic activity in animals, while aminobisphosphonates exacerbate experimental arthritis in mice. Further, aminobisphosphonate induce acute phase response in patients, while non-aminobisphosphonates do not. During the last few years, we have explored the effects of various bisphosphonates on the inflammatory processes in activated macrophages in vitro.

Keywords::

• bisphosphonates
• macrophages
• inflammation