Hybridization Properties and Polymerase Acceptance of Nitropiperonyl Deoxyriboside. Photochemical DNA Backbone Cleavage

Abstract

A novel C-nucleoside has been developed that can substitute for three of the four heterocyclic bases in double-stranded nucleic acids. It has the further property that it can be activated by light, leading to backbone cleavage and thereby dissociation of longer, double-stranded nucleic acids into shorter, single-stranded nucleic acids.

Keywords::

• nucleotides
• fragmentation
• photochemistry